Depression is the most common form of psychopathology affecting people in the US. It is commonly diagnosed and treated in primary medical care settings, creating a need for a reliable, quick self-report tool used for the assessment of depression in this context. There is a current shift in the way psychopathology is conceptualized, as the field transitions from a categorical, syndrome-based model to a dimensional model. This transition should be reflected in the assessment tool used within the primary care setting. The Multidimensional Behavioral Health Screen is being developed as a brief and efficient screening-level assessment tool for core psychopathology components (rather than syndromes), with a specific focus on depressive symptomatology. This study presents empirical evidence supporting the implementation of the MBHS as a reliable and valid mental health screener to be administered in primary care clinics.