The proposed research consisted of one study that examined the relationship between humor styles and happiness among people with a chronic illness, specifically Multiple Sclerosis (MS). In this study, we used correlational methods to test the hypothesis that a self-enhancing humor style relates positively to happiness and negatively to anxiety. That is, to the extent people habitually use self-enhancing humor to joke about their illness, they should report being generally happier and less anxious. We distributed a survey compromised of four measures to assess participant’s levels of happiness, anxiety, perceived stress in their daily lives, and the degree to which they used self-enhancing humor. Our findings supported the hypothesis that people who have Multiple Sclerosis and a self-enhancing humor style tend to be happier and less anxious because they perceive less stress in their daily lives.